Synthesis and antimalarial activity of 2-methoxyprop-2-yl peroxides derivatives

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

2-Methoxyprop-2-yl peroxides were synthesized and evaluated in vitro against Plasmodium falciparum. These acyclic artemisinin-related peroxides revealed moderate to good activity but were devoid of alkylating property towards the synthetic model of heme Mn(II)-TPP.

Knowledge Graph

Similar Paper