A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

The synthesis and anti-Helicobacter pylori activity of a novel agent NE2001, 4-(4-methylbenzyl)-4'-[guanidinomethylbenzoyloxy] biphenyl-4-carboxylate hydrochloride, are described. NE2001 had a specific inhibitory effect on the growth of H. pylori preceded by the suppression DNA synthesis in the cell. The effects of NE2001 on RNA and protein syntheses in H. pylori were also examined.

Knowledge Graph

Similar Paper

A specific anti-Helicobacter pylori agent NE2001: synthesis and its effect on the growth of H. pylori
Bioorganic & Medicinal Chemistry Letters 2003.0
Anti-Helicobacter pyloriAgents. 3. 2-[(Arylalkyl)guanidino]-4-furylthiazoles
Journal of Medicinal Chemistry 1999.0
Synthesis of a piperidinomethylthiophene derivative as H2-antagonist with inhibitory activity against Helicobacter pylori
Bioorganic & Medicinal Chemistry Letters 1996.0
Discovery of a novel benzyloxyisoquinoline derivative with potent anti-Helicobacter pylori activity
Bioorganic & Medicinal Chemistry Letters 1998.0
Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells
European Journal of Medicinal Chemistry 2012.0
Anti-HelicobacterpyloriAgents. 4. 2-(Substituted guanidino)-4-phenylthiazoles and Some Structurally Rigid Derivatives
Journal of Medicinal Chemistry 2000.0
Anti- Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles
Bioorganic & Medicinal Chemistry Letters 1998.0
Pyrazolopyrimidinediones Are Selective Agents for Helicobacter pylori That Suppress Growth through Inhibition of Glutamate Racemase (MurI)
Antimicrobial Agents and Chemotherapy 2009.0
3-(Arylacetylamino)-N-methylbenzamides:  A Novel Class of Selective Anti-Helicobacter pylori Agents
Journal of Medicinal Chemistry 2001.0
Synthesis and in vitro selective anti-Helicobacter pylori activity of pyrazoline derivatives
Bioorganic & Medicinal Chemistry Letters 2005.0