2-Piperidin-4-yl-benzimidazoles with broad spectrum antibacterial activities

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

A series of 2-piperidin-4-yl-benzimidazoles were synthesized and evaluated for antibacterial activities. Certain compounds inhibit bacterial growth with low micromolar minimal inhibitory concentration (MIC). These benzimidazoles are effective against both Gram-positive and Gram-negative bacteria of clinical importance, particularly enterococci, and represent a new class of potential antibacterial agents.

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