Synthesis of pyrimidinopyridine–triazene conjugates targeted to abl tyrosine kinase

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

The synthesis and abl tyrosine kinase inhibitory activities of alkyltriazenes conjugated to phenylaminopyrimidines are described. Significant abl inhibitory activities were observed only when a benzamido spacer was inserted between the 1,2,3-triazene chain and the 2-phenyaminopyridopyrimidine moiety.

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