1-Aryl-6,7-methylenedioxy-3 H -quinazolin-4-ones as anticonvulsant agents

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

A set of novel 1-aryl-6,7-methylenedioxy-3H-quinazolin-4-(thi)ones (3a-f) has been designed and screened as anticonvulsant agents in DBA/2 mice. The new compounds are provided with anticonvulsant properties comparable to those of GYKI 52466. To clarify the mode of action, their affinity for the quinazolinone/2,3-benzodiazepine site of the AMPA receptor complex has been assayed.

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