Duloxetine (Cymbalta™), a dual inhibitor of serotonin and norepinephrine reuptake

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta) has proven to be effective in clinical trials for the treatment of depression.

Knowledge Graph

Similar Paper

Duloxetine (Cymbalta™), a dual inhibitor of serotonin and norepinephrine reuptake
Bioorganic & Medicinal Chemistry Letters 2003.0
N-(1,2-Diphenylethyl)piperazines: A new class of dual serotonin/noradrenaline reuptake inhibitor
Bioorganic & Medicinal Chemistry Letters 2006.0
3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors
Bioorganic & Medicinal Chemistry Letters 2009.0
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors
Bioorganic & Medicinal Chemistry 2011.0
Discovery of N-methyl-1-(1-phenylcyclohexyl)ethanamine, a novel triple serotonin, norepinephrine and dopamine reuptake inhibitor
Bioorganic & Medicinal Chemistry Letters 2011.0
Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor
Bioorganic & Medicinal Chemistry Letters 2011.0
Synthesis of 1,1-[1-Naphthyloxy-2-thiophenyl]-2-methylaminomethylcyclopropanes and Their Evaluation as Inhibitors of Serotonin, Norepinephrine, and Dopamine Transporters
Journal of Medicinal Chemistry 2009.0
Synthesis and activity of 1-(3-amino-1-phenylpropyl)indolin-2-ones: A new class of selective norepinephrine reuptake inhibitors
Bioorganic & Medicinal Chemistry Letters 2008.0
Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression
Bioorganic & Medicinal Chemistry 2009.0
Dual NK1 antagonists—serotonin reuptake inhibitors as potential antidepressants. Part 2: SAR and activity of benzyloxyphenethyl piperazine derivatives
Bioorganic & Medicinal Chemistry Letters 2002.0