Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TRβ subtype-selective thyromimetics

Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TRβ subtype-selective thyromimetics A new class of high affinity thyromimetics containing a phenyl-naphthylene core Design, synthesis, and structure–activity relationship (SAR) of N-[7-(4-hydroxyphenoxy)-6-methylindan-4-yl]malonamic acids as thyroid hormone receptor β (TRβ) selective agonists Thyroid receptor ligands. Part 8: Thyromimetics derived from N-acylated-α-amino acid derivatives displaying modulated pharmacological selectivity compared with KB-141 Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor β Agonist A New Series of Estrogen Receptor Modulators That Display Selectivity for Estrogen Receptor β Structural Determinants of Selective Thyromimetics Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis Thyroid hormone analogs. Synthesis of 3'-substituted 3,5-diiodo-L-thyronines and quantitative structure-activity studies of in vitro and in vivo thyromimetic activities in rat liver and heart