Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines

Journal of Medicinal Chemistry
1980.0

Abstract

A continuous spectrophotometric assay for thymidine phosphorylase has been developed and used to analyze the substrate properties of a number of 5-substituted 2'-deoxyuridines. A QSAR was found which relates the catalytic efficiency for various substrates to a single variable, the inductive field constant F.

Knowledge Graph

Similar Paper

Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines
Journal of Medicinal Chemistry 1980.0
Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship
Journal of Medicinal Chemistry 1977.0
Kinetic parameters and recognition of thymidine analogues with varying functional groups by thymidine phosphorylase
Bioorganic & Medicinal Chemistry 2008.0
Thymidylate synthetase inhibitors. Synthesis of N-substituted 5-aminomethyl-2'-deoxyuridine 5'-phosphates
Journal of Medicinal Chemistry 1977.0
Thiopurine methyltransferase: structure-activity relationships for benzoic acid inhibitors and thiophenol substrates
Journal of Medicinal Chemistry 1986.0
Synthesis and biological evaluation of neutral derivatives of 5-fluoro-2'-deoxyuridine 5'-phosphate
Journal of Medicinal Chemistry 1983.0
Design of novel N-(2,4-dioxo-1,2,3,4-tetrahydro-thieno[3,2-d]pyrimidin-7-yl)-guanidines as thymidine phosphorylase inhibitors, and flexible docking to a homology model
Bioorganic & Medicinal Chemistry Letters 2003.0
Understanding the Binding of 5-Substituted 2‘-Deoxyuridine Substrates to Thymidine Kinase of Herpes Simplex Virus Type-1
Journal of Medicinal Chemistry 1996.0
Structure–activity relationship of 2,4,5-trioxoimidazolidines as inhibitors of thymidine phosphorylase
European Journal of Medicinal Chemistry 2011.0
Interaction of 1-(5-phospho-.beta.-D-arabinofuranosyl)-5-substituted-uracils with thymidylate synthetase: mechanism-based inhibition by 1-(5-phospho-.beta.-D-arabinofurosyl)-5-fluorouracil
Journal of Medicinal Chemistry 1981.0