Synthesis of (+),(−)-neamine and their positional isomers as potential antibiotics

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

The syntheses of (+)-neamine 1, (-)-neamine ent-1 and their positional isomers 2, 3, ent-2 and ent-3 are reported as potential new scaffolds for novel aminoglycoside antibiotics. These isomers exhibit similar inhibitory activities, as shown using an in vitro translation assay. A simple model is proposed to explain this lack of stereospecific binding to the ribosomal RNA.

Knowledge Graph

Similar Paper