Literature

Abstract

3'R,4'R-Di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP) (2) was designed and synthesized on the basis of a structure-activity relationship study of 3'R,4'R-di-O-(-)-camphanoyl-(+)-cis-khellactone DCK (1) and its analogues. DCP (2), a pyranochromone, and DCK (1), a pyranocoumarin, have different skeletons. Compound 2 showed potent in vitro inhibition of HIV-1 replication in H9 lymphocyte cells with an EC(50) of 6.78 x 10(-4) microM and TI of 14,500. These values are comparable with those for DCK (1) and better than those of AZT in the same assay.

DOI： 10.1016/s0960-894x(03)00201-4

Anti-HIV Agents. Part 55: 3′R,4′R-Di-(O)-(−)-camphanoyl-2′,2′-dimethyldihydropyrano[2,3-f]chromone (DCP), a Novel Anti-HIV agent

Bioorganic & Medicinal Chemistry Letters 2003.0

Anti-AIDS Agents. 60. Substituted 3‘R,4‘R-Di-O-(−)-camphanoyl-2‘,2‘-dimethyldihydropyrano[2,3-f]chromone (DCP) Analogues as Potent Anti-HIV Agents

Journal of Medicinal Chemistry 2004.0

Anti-AIDS agents. Part 47: synthesis and anti-HIV activity of 3-substituted 3′,4′-Di-O-(S)-camphanoyl-(3′R,4′R)-(+)-cis-khellactone derivatives

Bioorganic & Medicinal Chemistry Letters 2001.0

Anti-aids agents 33.1 Synthesis and anti-HIV activity of mono-methyl substituted 3′,4′-di-O-(−)-camphanoyl-(+)-cis-khellactone (DCK) analogues

Bioorganic & Medicinal Chemistry Letters 1998.0

Anti-AIDS Agents. 42. Synthesis and Anti-HIV Activity of Disubstituted (3‘R,4‘R)-3‘,4‘-Di-O-(S)-camphanoyl-(+)-cis-khellactone Analogues

Journal of Medicinal Chemistry 2001.0

Anti-AIDS agents-XXVIII.1 Synthesis and Anti-HIV activity of methoxy substituted 3′,4′-Di-O-(−)-camphanoyl-(+)-cis-khellactone (DCK) analogues