3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

For LVA T-type Ca2+ channel blockers, 3,4-dihydroquinazoline derivatives as new scaffolds were prepared and evaluated for the inhibitory activity against two members of the recombinant T-type Ca2+ channel family. Among them, 8a (KYS05001, IC50=0.9 microM) was nearly equipotent with mibefradil (IC50=0.84 microM) and inhibited LVA T-type Ca2+ channel with greater efficacy than HVA Ca2+ channel.

DOI： 10.1016/j.bmcl.2004.04.090

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