6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

A series of 6-arylamino-7-chloro-quinazoline-5,8-diones were prepared and evaluated for their in vitro cytotoxicity in cultured human cancer cell lines A549 (lung cancer), Col2 (colon cancer), and SNU-638 (stomach cancer). The preliminary structure-activity relationship has been described for providing further development of potent antitumor agents. To further investigate the cytotoxic mechanism, the effects of test compounds on DNA topoisomerase I and II activities have been assessed.

Knowledge Graph

Similar Paper

6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents
Bioorganic & Medicinal Chemistry Letters 2004.0
Substituted 2-arylquinazolinones: Design, synthesis, and evaluation of cytotoxicity and inhibition of topoisomerases
European Journal of Medicinal Chemistry 2015.0
Synthesis of 6-chloroisoquinoline-5,8-diones and pyrido[3,4-b]phenazine-5,12-diones and evaluation of their cytotoxicity and DNA topoisomerase II inhibitory activity
Bioorganic & Medicinal Chemistry 2007.0
Synthesis, Cytotoxicity, DNA Interaction, and Topoisomerase II Inhibition Properties of Novel Indeno[2,1-c]quinolin-7-one and Indeno[1,2-c]isoquinolin-5,11-dione Derivatives
Journal of Medicinal Chemistry 2008.0
Synthesis, cytotoxic activities and structure–activity relationships of topoisomerase I inhibitors: Indolizinoquinoline-5,12-dione derivatives
Bioorganic & Medicinal Chemistry 2008.0
Synthesis and cytotoxic activities of 6-chloro-7-arylamino-5,8-isoquinolinediones
Bioorganic & Medicinal Chemistry Letters 1999.0
Synthesis, cytotoxicity, and DNA topoisomerase II inhibitory activity of benzofuroquinolinediones
Bioorganic & Medicinal Chemistry 2007.0
Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors
European Journal of Medicinal Chemistry 2015.0
Synthesis of new 3-Arylisoquinolinamines: effect on topoisomerase I inhibition and cytotoxicity
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis, cytotoxicity and topoisomerase inhibition properties of multifarious aminoalkylated indeno[1,2-c]isoquinolin-5,11-diones
Bioorganic & Medicinal Chemistry Letters 2011.0