Synthesis of S-alkyl l-homocysteine analogues of glutathione and their kinetic studies with γ-glutamyl transpeptidase

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

A series of S-alkyl L-homocysteine analogues of glutathione was synthesized with varied oxidation state of the sulfur and tested for inhibition of rat kidney gamma-glutamyl transpeptidase (GGT). The strong selectivity of the enzyme with respect to the sulfur oxidation state reveals important information for the development of powerful competitive inhibitors.

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