Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

The synthesis of several novel coumarin derivatives with a 7-azomethine linkage was carried out starting from 7-formyl-coumarin. The compounds were tested in vivo for their anti-inflammatory activity and in vitro for their antioxidant ability. Compounds 3a and 3e possess significant protection against carrageenin induced rat paw edema.

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