Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

A class of flavanoids exhibiting a high degree of selectivity for ERalpha over ERbeta has been discovered. The most active analogue 6 was found to be 66-fold ERalpha-selective and demonstrated uterine estradiol antagonism.

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