π-Delocalized β-carbolinium cations as potential antimalarials

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

Several beta-carboline compounds including natural products and their corresponding salts were synthesized and evaluated for antimalarial activity and cytotoxicity levels. Quaternary carbolinium cations showed much higher potencies than neutral beta-carbolines and a good correlation was observed between pi-delocalized lipophilic cationic structure and antimalarial efficacy.

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