DNA binding ligands with in vivo efficacy in murine models of bacterial infection: optimization of internal aromatic amino acids

DNA binding ligands with in vivo efficacy in murine models of bacterial infection: optimization of internal aromatic amino acids Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-Positive antibacterial activity Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors Antibacterial and Solubility Optimization of Thiomuracin A Pentamidine congeners. 4. DNA binding affinity and anti-Pneumocystis carinii activity of butamidine analogues Aryl urea analogs with broad-spectrum antibacterial activity Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligase Structure–activity relationships of bivalent aminoglycosides and evaluation of their microbiological activities Synthesis, antimicrobial activity, attenuation of aminoglycoside resistance in MRSA, and ribosomal A-site binding of pyrene-neomycin conjugates Benzene-1,3-dicarboxylic acid 2,5-dimethylpyrrole derivatives as multiple inhibitors of bacterial Mur ligases (MurC–MurF)