A series of 4- [ (aryloxy)alkyl]pyrazoles has been prepared and evaluated in vitro against Herpes simplex virus type 2. Several compounds exhibited minimum inhibitory concentrations in the range of 0.7-6 µg/mL. Some of the more active homologues were evaluated in vivo in the mouse genital model against Herpes simplex virus (HSV) types 1 and 2. At a concentration of 5%, an aqueous solution of compound 3 exhibited a 60% survival rate against HSV-1 and 90% against HSV-2.