Tryptophan analogs. 1. Synthesis and antihypertensive activity of positional isomers

Journal of Medicinal Chemistry
1982.0

Abstract

A series of tryptophan analogues having the carboxyl function at the beta-position was synthesized and tested for antihypertensive activity. The 5-methoxy analogue 46 exhibited antihypertensive activity in the rat via the oral route and was much more potent than the normal tryptophan analogue. The methyl ester was found to be a critical structural feature for activity.

Knowledge Graph

Similar Paper