Synthesis and Biological Evaluation of Novel Cyclosporin A Analogues:  Potential Soft Drugs for the Treatment of Autoimmune Diseases

Journal of Medicinal Chemistry
2003.0

Abstract

Cyclosporin A is effective in the treatment of asthma patients, but its chronic use is limited by toxicity. Novel cyclosporin A analogues were synthesized utilizing the olefin metathesis reaction and evaluated in a calcineurin A inhibition assay. The novel analogues demonstrated activity comparable to activity of the parent molecule and are potential soft drugs.

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