Synthesis of potential antifilarial agents. 1. 1-(5-Benzoylbenzimidazol-2-yl)-3-alkyl and aryl ureas

Journal of Medicinal Chemistry
1984.0

Abstract

A series of 1-(5-benzoylbenzimidazol-2-yl)-3-substituted ureas have been synthesized by reacting an appropriate isocyanate with 2-amino-5-benzoylbenzimidazole or by reacting methyl (5-benzoylbenzimidazol-2-yl)carbamate with various amines. Several of the compounds have demonstrated antifilarial activity against Brugia pahangi and Litomosoides carinii.

Knowledge Graph

Similar Paper

Synthesis of potential antifilarial agents. 1. 1-(5-Benzoylbenzimidazol-2-yl)-3-alkyl and aryl ureas
Journal of Medicinal Chemistry 1984.0
Synthesis and biological activity of certain alkyl 5-(alkoxycarbonyl)-1H-benzimidazole-2-carbamates and related derivatives: a new class of potential antineoplastic and antifilarial agents
Journal of Medicinal Chemistry 1992.0
Synthesis and antifilarial activity of N-[4-[[4-alkoxy-3-[(dialkylamino)methyl]phenyl]amino]-2-pyrimidinyl]-N'-phenylguanidines
Journal of Medicinal Chemistry 1983.0
Synthesis and anthelmintic activity of 5(6)-[(benzimidazol-2-yl)carboxamido]- and (4-substituted piperazin-1-yl)benzimidazoles
Journal of Medicinal Chemistry 1985.0
Synthesis and anthelmintic activity of 3'-benzoylurea derivatives of 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole
Journal of Medicinal Chemistry 1991.0
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics
Journal of Medicinal Chemistry 1986.0
Synthesis and antiparasitic and antifungal evaluation of 2′-arylsubstituted-1H,1′H-[2,5′]bisbenzimidazolyl-5-carboxamidines
European Journal of Medicinal Chemistry 2009.0
Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenzimidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense
Bioorganic & Medicinal Chemistry 2016.0
New antifilarial agents. 1. Epoxy sulfonamides and ethynesulfonamides
Journal of Medicinal Chemistry 1987.0
Synthesis and antiparasitic activity of 1H-benzimidazole derivatives
Bioorganic & Medicinal Chemistry Letters 2002.0