Angiotensin converting enzyme inhibitors. 9. Novel [[N-(1-carboxyl-3-phenylpropyl)amino]acyl]glycine derivatives with diuretic activity

Journal of Medicinal Chemistry
1990.0

Abstract

A series of molecules 1 having sulfonamide diuretic moieties covalently linked to non-sulfhydryl angiotensin-converting enzyme inhibitors (ACEI) were prepared and tested for both activities. IC50 values for ACEI as low as 7 nM were observed. Discernable diuretic activity was seen for several hydrochlorothiazide-based molecules. Effects of the ACEI and diuretic structures on the respective potencies are discussed.

Knowledge Graph

Similar Paper

Angiotensin converting enzyme inhibitors. 9. Novel [[N-(1-carboxyl-3-phenylpropyl)amino]acyl]glycine derivatives with diuretic activity
Journal of Medicinal Chemistry 1990.0
Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives
Journal of Medicinal Chemistry 1990.0
Angiotensin converting enzyme inhibitors: N-Substituted monocyclic and bicyclic amino acid derivatives
Journal of Medicinal Chemistry 1983.0
Studies on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic acid derivatives
Journal of Medicinal Chemistry 1989.0
Angiotensin-converting enzyme inhibitors. 2. Perhydroazepin-2-one derivatives
Journal of Medicinal Chemistry 1988.0
Angiotensin-converting enzyme inhibitors. New orally active antihypertensive (mercaptoalkanoyl)- and [(acylthio)alkanoyl]glycine derivatives
Journal of Medicinal Chemistry 1985.0
Angiotensin converting enzyme inhibitors: 1-glutarylindoline-2-carboxylic acid derivatives
Journal of Medicinal Chemistry 1983.0
Antihypertensive agents: angiotensin converting enzyme inhibitors. 1-[3-(Acylthio)-3-aroylpropionyl]-L-prolines
Journal of Medicinal Chemistry 1983.0
Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types
Journal of Medicinal Chemistry 1986.0
Angiotensin-converting enzyme inhibitors. Perhydro-1,4-thiazepin-5-one derivatives
Journal of Medicinal Chemistry 1987.0