Synthesis and anaerobic activity of novel 1-carba-1-dethiacephalosporins

Journal of Medicinal Chemistry
1993.0

Abstract

The synthesis and biological evaluation of novel 1-carba-1-dethiacephalosporins exhibiting activity against anaerobic pathogens are described. The nitrothiazole substituent was determined to be crucial to maintaining this activity. The pharmacokinetic parameters and initial toxicological profile of the lead compound are discussed.

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