Editor's NoteThe present Perspective is the second in a two-part, in-depth overview of the current status of a- and P-adrenoceptor pharmacology and medicinal chemistry. The first part was published in the previous issue. (Hieble, J. P.; Bondinell, W.; Ruffolo, R. R., Jr. a- and P-Adrenoceptors: From the Gene to the Clinic. 1. Molecular Biology and Adrenoceptor Subclassification. J. Med. Chem. 1995,38, 3415-3444.)