Synthesis of some diguanidino 1-methyl-2,5-diaryl-1H-pyrroles as antifungal agents

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

A series of novel 2,5-bis(guanidino-aryl)-1-methyl-1H-pyrroles 9a-h has been synthesized starting from 1-methyl-1H-pyrrole. The antifungal activities of compounds were evaluated by in vitro agar diffusion and broth dilution assay against Candida spp. and Aspergillus spp. Compound 9c from this series was found to be equipotent or more potent than fluconazole, whereas compound 9d was comparable to fluconazole against most of the tested strains.

Knowledge Graph

Similar Paper

Synthesis of some diguanidino 1-methyl-2,5-diaryl-1H-pyrroles as antifungal agents
Bioorganic & Medicinal Chemistry Letters 2005.0
2-Acylhydrazino-5-arylpyrrole derivatives: Synthesis and antifungal activity evaluation
European Journal of Medicinal Chemistry 2009.0
Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives as antibacterial and antifungal agents
European Journal of Medicinal Chemistry 2010.0
Antifungal Agents. 9. 3-Aryl-4-[.alpha.-(1H-imidazol-1-yl)arylmethyl]pyrroles: A New Class of Potent Anti-Candida Agents
Journal of Medicinal Chemistry 1995.0
Synthesis of New Linear Guanidines and Macrocyclic Amidinourea Derivatives Endowed with High Antifungal Activity against Candida spp. and Aspergillus spp.
Journal of Medicinal Chemistry 2009.0
Design, synthesis and antifungal activities of novel pyrrole alkaloid analogs
European Journal of Medicinal Chemistry 2011.0
Synthesis and antifungal activities of new fluconazole analogues with azaheterocycle moiety
Bioorganic & Medicinal Chemistry Letters 2007.0
Design, synthesis and antifungal evaluation of 1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-1,2,4-triazol-5(4H)-one
European Journal of Medicinal Chemistry 2011.0
Design, synthesis and evaluation of hydrazine and acyl hydrazone derivatives of 5-pyrrolidin-2-one as antifungal agents
Bioorganic & Medicinal Chemistry Letters 2020.0
Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase (CYP51)
European Journal of Medicinal Chemistry 2007.0