Literature

Abstract

Unsaturated fatty acid amides, 9(Z)-octadecenamide (2) and 9(Z),12(Z)-octadecadienamide (4) as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT) were isolated from the ethyl acetate extracts of the insect, Mylabris phalerate Pallas, and elucidated by their spectroscopic data analysis. Compounds 2 and 4 inhibited rat liver microsomal ACAT, hACAT-1, and hACAT-2 with IC(50) values of 170, 85, and 63 microM for 2 and of 151, 53, and 45 microM for 4, respectively.

DOI： 10.1016/j.bmcl.2004.05.086

Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas

Bioorganic & Medicinal Chemistry Letters 2004.0

Human Acyl-CoA: Cholesterol Acyltransferase Inhibitory Activities of Aliphatic Acid Amides from Zanthoxylum piperitum DC.

Biological and Pharmaceutical Bulletin 2007.0

Polyunsaturated fatty acid anilides as inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT)

Bioorganic & Medicinal Chemistry Letters 1999.0

Lateritin, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Gibberella lateritium IFO 7188.

The Journal of Antibiotics 1993.0

GERI-BP001 Compounds, New Inhibitors of Acyl-CoA: Cholesterol Acyltransferase from Aspergillus fumigatus F37. I. Production, Isolation, and Physico-chemical and Biological Properties.

The Journal of Antibiotics 1995.0

Isochromophilones III -VI, Inhibitors of Acyl-CoA: Cholesterol Acyltransferase Produced by Penicillium multicolor FO-3216.