Optimization of Substituted N-3-Benzylimidazoquinazolinone Sulfonamides as Potent and Selective PDE5 Inhibitors

Optimization of Substituted N-3-Benzylimidazoquinazolinone Sulfonamides as Potent and Selective PDE5 Inhibitors N-3-Substituted Imidazoquinazolinones:  Potent and Selective PDE5 Inhibitors as Potential Agents for Treatment of Erectile Dysfunction Comparison of different heterocyclic scaffolds as substrate analog PDE5 inhibitors Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction Quinazolines as potent and highly selective PDE5 inhibitors as potential therapeutics for male erectile dysfunction 2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6 Synthesis and phosphodiesterase 5 inhibitory activity of new sildenafil analogues containing a phosphonate group in the 5 ′ -sulfonamide moiety of phenyl ring Structure−Activity Relationships of N-Acyl Pyrroloquinolone PDE-5 Inhibitors Furoyl and Benzofuroyl Pyrroloquinolones as Potent and Selective PDE5 Inhibitors for Treatment of Erectile Dysfunction Design, synthesis and evaluation of N2,N4-diaminoquinazoline based inhibitors of phosphodiesterase type 5