Synthesis and GABA receptor potency of 3-thiomethyl-4-(hetero)aryl-5-amino-1-phenylpyrazoles

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

A convenient synthetic route to novel 4-arylpyrazoles is described. The potential for insecticidal activity through GABA channel blockage by this series of compounds, as well as their selectivity for insect versus mammalian receptors, are explored through in vitro and in vivo assays.

Knowledge Graph

Similar Paper

Synthesis and GABA receptor potency of 3-thiomethyl-4-(hetero)aryl-5-amino-1-phenylpyrazoles
Bioorganic & Medicinal Chemistry Letters 2004.0
5-Amino-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-3-[3H3]-methylsulfanyl-1H-pyrazole-4-carbonitrile (CTOM): Synthesis and Characterization of a Novel and Selective Insect GABA Receptor Radioligand
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis and pharmacological evaluation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as potential GABAA-R ligands
Bioorganic & Medicinal Chemistry 2017.0
Fipronil-based photoaffinity probe for Drosophila and human β3 GABA receptors
Bioorganic & Medicinal Chemistry Letters 2001.0
Aminomethyltetrazoles as potential inhibitors of the γ-aminobutyric acid transporters mGAT1–mGAT4: Synthesis and biological evaluation
Bioorganic & Medicinal Chemistry 2011.0
Synthesis and enzyme inhibitory activities of some new pyrazole-based heterocyclic compounds
Medicinal Chemistry Research 2012.0
Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1–mGAT4
European Journal of Medicinal Chemistry 2008.0
Synthesis and Biological Evaluation of 4-(Aminomethyl)-1-hydroxypyrazole Analogues of Muscimol as γ-Aminobutyric Acid<sub>A</sub> Receptor Agonists
Journal of Medicinal Chemistry 2013.0
3-(4-Phenoxyphenyl)pyrazoles:  A Novel Class of Sodium Channel Blockers
Journal of Medicinal Chemistry 2004.0
Synthesis, biological evaluation and structure–activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides
European Journal of Medicinal Chemistry 2014.0