Carbon Isosteres of the 4-Aminopyridine Substructure of Chloroquine:  Effects on pK_a, Hematin Binding, Inhibition of Hemozoin Formation, and Parasite Growth

Carbon Isosteres of the 4-Aminopyridine Substructure of Chloroquine:  Effects on pK_a, Hematin Binding, Inhibition of Hemozoin Formation, and Parasite Growth Structural Specificity of Chloroquine−Hematin Binding Related to Inhibition of Hematin Polymerization and Parasite Growth Structure−Function Relationships in Aminoquinolines:  Effect of Amino and Chloro Groups on Quinoline−Hematin Complex Formation, Inhibition of β-Hematin Formation, and Antiplasmodial Activity 4-N-, 4-S-, and 4-O-Chloroquine Analogues: Influence of Side Chain Length and Quinolyl Nitrogen pK_a on Activity vs Chloroquine Resistant Malaria Synthesis, Antiplasmodial Activity, and β-Hematin Inhibition of Hydroxypyridone–Chloroquine Hybrids 2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure–activity relationship and mode of action studies N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: Design, synthesis and antiplasmodial activity Novel Antimalarial Aminoquinolines: Heme Binding and Effects on Normal orPlasmodium falciparum-Parasitized Human Erythrocytes Synthesis and Antimalarial Activity of Side Chain Modified 4-Aminoquinoline Derivatives Kojic acid derived hydroxypyridinone–chloroquine hybrids: Synthesis, crystal structure, antiplasmodial activity and β-haematin inhibition