Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

Syntheses and excellent anti-MRSA activities of the mansonone F analogs are reported. In addition, the minimal structural requirements for its anti-MRSA activities as well as its structure-activity relationship including the C3 substituents effects on anti-MRSA activity are also described. In particular, this study revealed that both ortho-quinone and tricyclic systems of mansonone F are essential for anti-MRSA activities.

Knowledge Graph

Similar Paper

Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity
Bioorganic & Medicinal Chemistry Letters 2004.0
The structure–activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs
Bioorganic & Medicinal Chemistry Letters 2006.0
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents
Bioorganic & Medicinal Chemistry Letters 2016.0
Structure–activity relationship of indoloquinoline analogs anti-MRSA
Bioorganic & Medicinal Chemistry Letters 2015.0
Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors
European Journal of Medicinal Chemistry 2011.0
Structure–Activity Relationship and Anticancer Profile of Second-Generation Anti-MRSA Synthetic Retinoids
ACS Medicinal Chemistry Letters 2020.0
Anti-MRSA Sesquiterpenes from the Semi-Mangrove Plant Myoporum bontioides A. Gray
Marine Drugs 2018.0
Substituted 3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl) vinyl)-4H-chromen-4-ones as novel anti-MRSA agents: Synthesis, SAR, and in-vitro assessment
Bioorganic & Medicinal Chemistry Letters 2008.0
Modified tetra-oxygenated xanthones analogues as anti-MRSA and P. aeruginosa agent and their synergism with vancomycin
Bioorganic & Medicinal Chemistry Letters 2020.0
Synthesis and antibacterial activity study of a novel class of cationic anthraquinone analogs
Bioorganic & Medicinal Chemistry 2011.0