Synthesis and biological evaluation of gemcitabine–lipid conjugate (NEO6002)

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

A novel gemcitabine-lipid conjugate 5 was synthesized and tested for its in vivo efficacy and toxicity. Compound 5 was tested in BxPC-3 human pancreatic tumor model in SCID mice and exhibited promising activity and lower toxicity when compared with Gemzar.

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