Synthesis and biological studies of yohimbine derivatives on human α2C-adrenergic receptors

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

A series of yohimbine derivatives was synthesized and evaluated for binding affinity at the human alpha(2C)-adrenergic receptors expressed in Chinese hamster ovary cells. It has been found that compound 5 shows a higher affinity for alpha(2C)-AR than the parent compound yohimbine 1, thereby illustrating that the nature of the linkers affect binding potencies on these receptors.

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