Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

A series of (1,4)-naphthoquinono [3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives 2-7 were synthesized and evaluated for antifungal, antibacterial, and anticancer activities. The structure-activity relationship of these compounds was studied and the results show that the compound 2b exhibited in vitro antifungal activity against Candida albicans and Cryptococcus neoformans, and also possessed antibacterial profile against Klebsiella pneumoniae and Escherichia coli whereas 1c showed anticancer activity against Walker 256 Carcinosarcoma in rats.

Knowledge Graph

Similar Paper

Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents
Bioorganic & Medicinal Chemistry Letters 2005.0
Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents
Bioorganic & Medicinal Chemistry Letters 2004.0
Synthesis of novel 1,4-naphthoquinone derivatives: antibacterial and antifungal agents
Medicinal Chemistry Research 2013.0
Synthesis and biological evaluation of novel (l)-α-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents
Bioorganic & Medicinal Chemistry Letters 2005.0
Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents
Bioorganic & Medicinal Chemistry Letters 2004.0
Synthesis of novel quinoline–based 4,5–dihydro–1 H –pyrazoles as potential anticancer, antifungal, antibacterial and antiprotozoal agents
European Journal of Medicinal Chemistry 2017.0
Design, synthesis and biological evaluation of novel nitrogen and sulfur containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents
European Journal of Medicinal Chemistry 2009.0
2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: Synthesis and Biological evaluation as potential antiproliferative and antifungal agents
European Journal of Medicinal Chemistry 2009.0
Synthesis, in vitro antimicrobial and in vivo antitumor evaluation of novel pyrimidoquinolines and its nucleoside derivatives
European Journal of Medicinal Chemistry 2011.0
Synthesis and SAR study of novel anticancer and antimicrobial naphthoquinone amide derivatives
Bioorganic & Medicinal Chemistry Letters 2014.0