Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

A series of 2-phenoxy-indan-1-one derivatives have been designed, synthesized, and tested as acetylcholinesterase inhibitors. The most potent compound exhibited high AChE inhibitory activity (IC50 = 50 nM), and the molecular docking study indicated that it was nicely accommodated by AChE.

Knowledge Graph

Similar Paper

Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry Letters 2005.0
2-Phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors: A study on the importance of modifications at the side chain on the activity
Bioorganic & Medicinal Chemistry 2008.0
Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents
Bioorganic & Medicinal Chemistry Letters 2012.0
Design, synthesis and pharmacological evaluation of some novel indanone derivatives as acetylcholinesterase inhibitors for the management of cognitive dysfunction
Bioorganic & Medicinal Chemistry 2018.0
Indolinone-based acetylcholinesterase inhibitors: Synthesis, biological activity and molecular modeling
European Journal of Medicinal Chemistry 2014.0
Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry 2013.0
Synthesis and Structure-Activity Relationships of Acetylcholinesterase Inhibitors: 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine Hydrochloride and Related Compounds
Journal of Medicinal Chemistry 1995.0
Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors
Bioorganic & Medicinal Chemistry 2009.0
Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors
European Journal of Medicinal Chemistry 2009.0
Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives
European Journal of Medicinal Chemistry 2009.0