Structure–activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

Antimicrobial activities of two azafluorenones, four 1-azaanthraquinones, five 2-azaanthraquinones, and one 2-azaquinone were tested. Several azaanthraquinones possessed broad, potent activity, while the azafluorenones demonstrated weak activity. The following structure-activity relationship was postulated: (1) activity decreased in the order 2-azaanthraquinones>1-azaanthraquinones>azafluorenones; and (2) a hydroxyl group at the peri-carbonyl group enhanced activity. In addition, correlations among reduction potential, hydrophobic parameter, and antimicrobial activity were discussed.

Knowledge Graph

Similar Paper

Structure–activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds
Bioorganic & Medicinal Chemistry Letters 2005.0
Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones
Journal of Medicinal Chemistry 1987.0
Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents
Journal of Medicinal Chemistry 1985.0
Fluoronaphthyridines and quinolones as antibacterial agents. 1. Synthesis and structure-activity relationship of new 1-substituted derivatives
Journal of Medicinal Chemistry 1989.0
Studies on synthesis and evaluation of quantitative structure–activity relationship of 10-methyl-6-oxo-5-arylazo-6,7-dihydro-5H-[1,3]azaphospholo[1,5-d][1,4]benzodiazepin-2-phospha-3-ethoxycarbonyl-1-phosphorus dichlorides
Bioorganic & Medicinal Chemistry Letters 2006.0
Urea/thiourea derivatives of quinazolinone–lysine conjugates: Synthesis and structure–activity relationships of a new series of antimicrobials
European Journal of Medicinal Chemistry 2011.0
Synthesis and antimicrobial activity of 2-fluorophenyl-4,6-disubstituted [1,3,5]triazines
Bioorganic & Medicinal Chemistry Letters 2010.0
Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids
Journal of Medicinal Chemistry 1980.0
Novel amino-substituted 3-quinolinecarboxylic acid antibacterial agents: synthesis and structure-activity relationships
Journal of Medicinal Chemistry 1984.0
Quantitative structure-activity relationships in 2,5-bis(1-aziridinyl)-p-benzoquinone derivatives against leukemia L-1210
Journal of Medicinal Chemistry 1979.0