Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2.

Knowledge Graph

Similar Paper

Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities
Bioorganic & Medicinal Chemistry Letters 2005.0
Synthesis and Evaluation of 7-Substituted 4-Aminoquinoline Analogues for Antimalarial Activity
Journal of Medicinal Chemistry 2011.0
Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline
Bioorganic & Medicinal Chemistry 2012.0
4-Aminoquinoline derived antimalarials: Synthesis, antiplasmodial activity and heme polymerization inhibition studies
European Journal of Medicinal Chemistry 2010.0
Synthesis, antimalarial activity and inhibition of haem detoxification of novel bisquinolines
Bioorganic & Medicinal Chemistry Letters 2001.0
Synthesis of 2-[3-(7-Chloro-quinolin-4-ylamino)-alkyl]-1-(substituted phenyl)-2,3,4,9-tetrahydro-1H-β-carbolines as a new class of antimalarial agents
Bioorganic & Medicinal Chemistry Letters 2008.0
N -Piperonyl substitution on aminoquinoline-pyrimidine hybrids: Effect on the antiplasmodial potency
European Journal of Medicinal Chemistry 2017.0
Synthesis and antimalarial activity of carbamate and amide derivatives of 4-anilinoquinoline
European Journal of Medicinal Chemistry 2008.0
New quinoline-5,8-dione and hydroxynaphthoquinone derivatives inhibit a chloroquine resistant Plasmodium falciparum strain
European Journal of Medicinal Chemistry 2012.0
Synthesis and Antimalarial Activity in Vitro and in Vivo of a New Ferrocene−Chloroquine Analogue
Journal of Medicinal Chemistry 1997.0