Design, synthesis and biological evaluation of novel bicyclic β-lactams as potential antimalarials
Bioorganic & Medicinal Chemistry Letters
2005.0
Abstract
A series of bicyclic N-substituted and unsubstituted beta-lactams were synthesized and evaluated as targeted potential antimalarials. The compounds MNR4 and MNR5 were found to have highest potency against Plasmodium falciparum in vitro.