Design, synthesis and biological evaluation of novel bicyclic β-lactams as potential antimalarials

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

A series of bicyclic N-substituted and unsubstituted beta-lactams were synthesized and evaluated as targeted potential antimalarials. The compounds MNR4 and MNR5 were found to have highest potency against Plasmodium falciparum in vitro.

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