Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

A series of mercaptoacetamides were designed and synthesized as novel histone deacetylase inhibitors with the aid of modeling. Their ability to inhibit HDAC activity and their effects on cancer cell growth were investigated. Some compounds exhibit better HDAC inhibitory activity than SAHA.

Knowledge Graph

Similar Paper

Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors
Bioorganic & Medicinal Chemistry Letters 2005.0
Fluoroalkene modification of mercaptoacetamide-based histone deacetylase inhibitors
Bioorganic & Medicinal Chemistry 2010.0
Design, synthesis and preliminary bioactivity studies of 1,2-dihydrobenzo[d]isothiazol-3-one-1,1-dioxide hydroxamic acid derivatives as novel histone deacetylase inhibitors
Bioorganic & Medicinal Chemistry 2014.0
Novel Inhibitors of Human Histone Deacetylases:  Design, Synthesis, Enzyme Inhibition, and Cancer Cell Growth Inhibition of SAHA-Based Non-hydroxamates
Journal of Medicinal Chemistry 2005.0
Design, synthesis and biological evaluation of saccharin-based N -hydroxybenzamides as histone deacetylases (HDACs) inhibitors
Bioorganic & Medicinal Chemistry 2015.0
Design, synthesis and preliminary bioactivity evaluations of substituted quinoline hydroxamic acid derivatives as novel histone deacetylase (HDAC) inhibitors
Bioorganic & Medicinal Chemistry 2015.0
Novel amide derivatives as inhibitors of histone deacetylase: Design, synthesis and SAR
European Journal of Medicinal Chemistry 2009.0
Thiol-based SAHA analogues as potent histone deacetylase inhibitors
Bioorganic & Medicinal Chemistry Letters 2004.0
Design and synthesis of a new generation of substituted purine hydroxamate analogs as histone deacetylase inhibitors
Bioorganic & Medicinal Chemistry 2016.0
Novel histone deacetylase inhibitors: design, synthesis, enzyme inhibition, and binding mode study of SAHA-Based non-hydroxamates
Bioorganic & Medicinal Chemistry Letters 2003.0