Synthesis and antibacterial activity of potent heterocyclic oxazolidinones and the identification of RBx 8700

Bioorganic & Medicinal Chemistry Letters
2007.0

Abstract

Several potent oxazolidinone antibacterial agents were obtained by systematic modification of the linker between the five-membered heterocycle and the piperazinyl ring of RBx 7644 (Ranbezolid, 1) and its thienyl analogue 2, leading to the identification of an expanded spectrum compound RBx 8700 (6b).

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