Synthesis and evaluation of a series of tropane analogues as novel vesicular monoamine transporter-2 ligands

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

A series of tropane derivatives has been synthesized as lobelane analogues and evaluated for their binding affinity at the vesicular monoamine transporter-2 (VMAT2), and at alpha4beta2* and alpha7* nicotinic acetylcholine receptors. The trop-2-ene analogues 4a and 4b exhibited good affinity and high selectivity for VMAT2.

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