Design, synthesis, and antiproliferative activity of some novel aminosubstituted xanthenones, able to overcome multidrug resistance toward MES-SA/Dx5 cells

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

A series of novel xanthenone aminoderivatives and their pyrazole-fused counterparts possessing structural analogy to the potent anticancer agent 9-methoxypyrazoloacridine (PZA) reported. These compounds exhibited an interesting cytotoxic activity against a panel of cell lines. Most noticeably, they retain activity against the multidrug resistant MES-SA/Dx5 subline, showing resistant factors close to 1.

Knowledge Graph

Similar Paper

Design, synthesis, and antiproliferative activity of some novel aminosubstituted xanthenones, able to overcome multidrug resistance toward MES-SA/Dx5 cells
Bioorganic & Medicinal Chemistry Letters 2005.0
Design, Synthesis, and Evaluation of the Antiproliferative Activity of a Series of Novel Fused Xanthenone Aminoderivatives in Human Breast Cancer Cells
Journal of Medicinal Chemistry 2007.0
Synthesis and antiproliferative activity of some novel benzo-fused imidazo[1,8]naphthyridinones
Bioorganic & Medicinal Chemistry Letters 2015.0
Synthesis and anticancer potential of novel xanthone derivatives with 3,6-substituted chains
Bioorganic & Medicinal Chemistry 2016.0
Design, synthesis and cell growth inhibitory activity of a series of novel aminosubstituted xantheno[1,2-d]imidazoles in breast cancer cells
Bioorganic & Medicinal Chemistry 2008.0
Design, Synthesis, and Antiproliferative Activity of Some New Pyrazole-Fused Amino Derivatives of the Pyranoxanthenone, Pyranothioxanthenone, and Pyranoacridone Ring Systems:  A New Class of Cytotoxic Agents
Journal of Medicinal Chemistry 2002.0
Synthesis and antiproliferative activity of aryl- and heteroaryl-hydrazones derived from xanthone carbaldehydes
European Journal of Medicinal Chemistry 2008.0
Dual-acting agents that possess reversing resistance and anticancer activities: Design, synthesis, MES-SA/Dx5 cell assay, and SAR of Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3′,4′:1,2]pyridin[3,4-b]indol-2-substitutedacetates
Bioorganic & Medicinal Chemistry 2007.0
Antitumor activities of some new 1,3,2-oxaza- and 1,3,2-diazaphosphorinanes against K562, MDA-MB-231, and HepG2 cells
Medicinal Chemistry Research 2012.0
Structure−Activity Relationships for Pyrido-, Imidazo-, Pyrazolo-, Pyrazino-, and Pyrrolophenazinecarboxamides as Topoisomerase-Targeted Anticancer Agents
Journal of Medicinal Chemistry 2002.0