A Novel Selective GABA_Aα1 Receptor Agonist Displaying Sedative and Anxiolytic-like Properties in Rodents

A Novel Selective GABA_Aα1 Receptor Agonist Displaying Sedative and Anxiolytic-like Properties in Rodents 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4- triazol-3-ylmethoxy)-3-(2-fluorophenyl)- 1,2,4-triazolo[4,3-b]pyridazine:  A Functionally Selective γ-Aminobutyric Acid_A(GABA_A) α2/α3-Subtype Selective Agonist That Exhibits Potent Anxiolytic Activity but Is Not Sedating in Animal Models Synthesis and Benzodiazepine Receptor Affinity of Pyrazolo[1,5-a]pyrimidine Derivatives. 3. New 6-(3-Thienyl) Series as α1 Selective Ligands Identification of a New Pyrazolo[1,5-a]quinazoline Ligand Highly Affine to γ-Aminobutyric Type A (GABA_A) Receptor Subtype with Anxiolytic-Like and Antihyperalgesic Activity Novel N-Substituted Indol-3-ylglyoxylamides Probing the L_Diand L₁/L₂Lipophilic Regions of the Benzodiazepine Receptor Site in Search for Subtype-Selective Ligands 4-Quinolone Derivatives:  High-Affinity Ligands at the Benzodiazepine Site of Brain GABA_AReceptors. Synthesis, Pharmacology, and Pharmacophore Modeling Search for α3β2/3γ2 subtype selective ligands that are stable on human liver microsomes Synthesis and pharmacological evaluation of pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives as potential GABAA-R ligands Discovery of Imidazo[1,2-b][1,2,4]triazines as GABA_A α2/3 Subtype Selective Agonists for the Treatment of Anxiety Potential Anxiolytic Agents. Part 4: Novel Orally-Active N5-Substituted Pyrido[1,2-a]benzimidazoles with High GABA-A Receptor Affinity