Synthesis of doxorubicin–peptide conjugate with multidrug resistant tumor cell killing activity

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

Cell penetrating peptide TAT was introduced into doxorubicin structure. Synthesized doxorubicin-TAT conjugate showed different intracellular distribution pattern and cell killing activity from those of free doxorubicin. Unlike free doxorubicin, doxorubicin-TAT conjugate was highly permeable to drug-resistant cells and was able to kill drug-resistant tumor cells efficiently.

Knowledge Graph

Similar Paper

Synthesis of doxorubicin–peptide conjugate with multidrug resistant tumor cell killing activity
Bioorganic & Medicinal Chemistry Letters 2005.0
Overcoming drug resistance by cell-penetrating peptide-mediated delivery of a doxorubicin dimer with high DNA-binding affinity
European Journal of Medicinal Chemistry 2017.0
Novel Peptide–Doxorubucin Conjugates for Targeting Breast Cancer Cells Including the Multidrug Resistant Cells
Journal of Medicinal Chemistry 2013.0
Synthesis and biological activity of conjugates between paclitaxel and the cell delivery vector penetratin
Bioorganic & Medicinal Chemistry Letters 2006.0
Synthesis and antiproliferative activities of doxorubicin thiol conjugates and doxorubicin-SS-cyclic peptide
European Journal of Medicinal Chemistry 2019.0
Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate
Bioorganic & Medicinal Chemistry Letters 2006.0
Novel Cell-Penetrating Peptide Conjugated Proteasome Inhibitors: Anticancer and Antifungal Investigations
Journal of Medicinal Chemistry 2020.0
Design of a doxorubicin-peptidomimetic conjugate that targets HER2-positive cancer cells
European Journal of Medicinal Chemistry 2017.0
Design and application of hybrid cyclic-linear peptide-doxorubicin conjugates as a strategy to overcome doxorubicin resistance and toxicity
European Journal of Medicinal Chemistry 2021.0
Discovery of novel cell-penetrating and tumor-targeting peptide-drug conjugate (PDC) for programmable delivery of paclitaxel and cancer treatment
European Journal of Medicinal Chemistry 2021.0