Anti-malarial activity of Baylis–Hillman adducts from substituted 2-chloronicotinaldehydes

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

New Baylis-Hillman adducts are synthesized based on substituted 2-chloronicotinaldehydes and screened for their in vitro anti-malarial activity against chloroquine sensitive and chloroquine resistant Plasmodium falciparum. Out of the six new compounds synthesized and screened, 2b, 2c and 2d compounds showed substantial anti-malarial activity.

Knowledge Graph

Similar Paper

Anti-malarial activity of Baylis–Hillman adducts from substituted 2-chloronicotinaldehydes
Bioorganic & Medicinal Chemistry Letters 2005.0
Synthesis of 2-[3-(7-Chloro-quinolin-4-ylamino)-alkyl]-1-(substituted phenyl)-2,3,4,9-tetrahydro-1H-β-carbolines as a new class of antimalarial agents
Bioorganic & Medicinal Chemistry Letters 2008.0
Synthesis of chlorovinyl sulfones as structural analogs of chalcones and their antiplasmodial activities
European Journal of Medicinal Chemistry 2009.0
Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts
Bioorganic & Medicinal Chemistry Letters 2004.0
Morita–Baylis–Hillman adducts: Biological activities and potentialities to the discovery of new cheaper drugs
Bioorganic & Medicinal Chemistry 2012.0
Design, synthesis and biological evaluation of some novel 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones as antimalarial agents
Medicinal Chemistry Research 2012.0
In Vitro Antimalarial Activity of Chalcones and Their Derivatives
Journal of Medicinal Chemistry 1995.0
Antimalarial activity of 2,6-dibenzylidenecyclohexanone derivatives
Bioorganic & Medicinal Chemistry Letters 2021.0
Syntheses and in Vitro Antiplasmodial Activity of Aminoalkylated Chalcones and Analogues
Journal of Natural Products 2015.0
Synthesis and in vitro evaluation of new chloroquine-chalcone hybrids against chloroquine-resistant strain of Plasmodium falciparum
Bioorganic & Medicinal Chemistry Letters 2012.0