Synthesis and biological evaluation of simplified mycothiazole analogues

Bioorganic & Medicinal Chemistry Letters
2006.0

Abstract

Thiazoline and oxazoline analogues of the natural product mycothiazole were synthesized from a common intermediate and evaluated in vitro against HCT-15 colon cancer cells and L(4) larvae of nematode Nippostrongylus brasiliensis. The nature of the heterocyclic moiety seems to modulate the cytotoxic or anthelmintic activity.

Knowledge Graph

Similar Paper

Synthesis and biological evaluation of simplified mycothiazole analogues
Bioorganic & Medicinal Chemistry Letters 2006.0
Mycothiazole, a polyketide heterocycle from a marine sponge
Journal of the American Chemical Society 1988.0
Synthesis and biological evaluation of thiazoline derivatives as new antimicrobial and anticancer agents
European Journal of Medicinal Chemistry 2014.0
Synthesis and in vitro study of methylene-bis-tetrahydro[1,3]thiazolo[4,5-c]isoxazoles as potential nematicidal agents
European Journal of Medicinal Chemistry 2010.0
Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8S Configuration
ACS Medicinal Chemistry Letters 2020.0
Synthesis and biological evaluation of lipid-like 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole derivatives as potential anticancer and antimicrobial agents
MedChemComm 2015.0
Synthesis, characterization and antiamoebic activity of some hydrazone and azole derivatives bearing pyridyl moiety as a promising heterocyclic scaffold
European Journal of Medicinal Chemistry 2012.0
Novel thiophenes and analogues with anthelmintic activity against Haemonchus contortus
Bioorganic & Medicinal Chemistry Letters 2004.0
Antitumor and antileishmanial evaluation of novel heterocycles derived from quinazoline scaffold: a molecular modeling approach
Medicinal Chemistry Research 2013.0
Synthesis, characterization, antiamoebic activity and cytotoxicity of novel 2-(quinolin-8-yloxy) acetohydrazones and their cyclized products (1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives)
European Journal of Medicinal Chemistry 2010.0