Novel indole inhibitors of IMPDH from fragments: Synthesis and initial structure–activity relationships

Bioorganic & Medicinal Chemistry Letters
2006.0

Abstract

The elaboration of previously reported indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis, in vitro inhibitory values for IMPDH II, PBMC proliferation and physicochemical properties are discussed.

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