N-Benzylbenzamides: A new class of potent tyrosinase inhibitors

Bioorganic & Medicinal Chemistry Letters
2006.0

Abstract

A series of potent inhibitors of tyrosinase and their structure-activity relationships are described. N-Benzylbenzamide derivatives (1-21) with hydroxyl(s) were synthesized and tested for their tyrosinase inhibitory activity. With this series, compound 15 provided a potent tyrosinase inhibition: it effectively inhibited the oxidation of l-DOPA catalyzed by mushroom tyrosinase with an IC(50) of 2.2microM.

Knowledge Graph

Similar Paper

N-Benzylbenzamides: A new class of potent tyrosinase inhibitors
Bioorganic & Medicinal Chemistry Letters 2006.0
Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted 5-benzylidene(thio) barbiturates as novel tyrosinase inhibitors
Bioorganic & Medicinal Chemistry 2014.0
Synthesis and structure–activity relationships of phenylpropanoid amides of serotonin on tyrosinase inhibition
Bioorganic & Medicinal Chemistry Letters 2011.0
Analogues of N-hydroxycinnamoylphenalkylamides as inhibitors of human melanocyte-tyrosinase
Bioorganic & Medicinal Chemistry Letters 2006.0
Anti-tyrosinase, antioxidant and antimicrobial activities of hydroxycinnamoylamides
Medicinal Chemistry Research 2013.0
Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors
Bioorganic & Medicinal Chemistry 2013.0
Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities
European Journal of Medicinal Chemistry 2009.0
Analogues of N-hydroxy-N′-phenylthiourea and N-hydroxy-N′-phenylurea as inhibitors of tyrosinase and melanin formation
Bioorganic & Medicinal Chemistry Letters 2008.0
Discovery of a new type of scaffold for the creation of novel tyrosinase inhibitors
Bioorganic & Medicinal Chemistry 2016.0
Synthesis of pyrazolo[4,3-e][1,2,4]triazine sulfonamides, novel Sildenafil analogs with tyrosinase inhibitory activity
Bioorganic & Medicinal Chemistry 2014.0