Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1

Bioorganic & Medicinal Chemistry Letters
2006.0

Abstract

The synthesis and preliminary structure-activity relationship of a series of pyrrolidinones are described. These pyrrolidinones have been characterized as novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) which are highly potent against wild-type and drug-resistant human immunodeficiency viruses (HIV-1).

Knowledge Graph

Similar Paper

Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1
Bioorganic & Medicinal Chemistry Letters 2006.0
Design, Synthesis, and SAR of a Novel Pyrazinone Series with Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitory Activity
Journal of Medicinal Chemistry 2005.0
Synthesis of new non-nucleoside inhibitors of HIV-1
Bioorganic & Medicinal Chemistry Letters 1996.0
Pyrazole NNRTIs 1: Design and initial optimisation of a novel template
Bioorganic & Medicinal Chemistry Letters 2009.0
Synthesis and biological activity of new pyridone diaryl ether non-nucleoside inhibitors of HIV-1 reverse transcriptase
MedChemComm 2010.0
Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs)
Bioorganic & Medicinal Chemistry 2011.0
Novel Pyridinone Derivatives As Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) with High Potency against NNRTI-Resistant HIV-1 Strains
Journal of Medicinal Chemistry 2013.0
Synthesis of Novel Diarylpyrimidine Analogues and Their Antiviral Activity against Human Immunodeficiency Virus Type 1
Journal of Medicinal Chemistry 2005.0
Design and synthesis of N1-aryl-benzimidazoles 2-substituted as novel HIV-1 non-nucleoside reverse transcriptase inhibitors
Bioorganic & Medicinal Chemistry 2014.0
Design, synthesis, and structure–activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents
Bioorganic & Medicinal Chemistry 2009.0