Literature

Abstract

The first activation study of isoform XIII of carbonic anhydrase (CA, EC 4.2.1.1) is reported. A series of amino acids and amines incorporating protonatable moieties of the primary/heterocyclic amine type were included in the study. As for CA I and II, CA XIII activators enhance kcat and show no effect on KM, for the physiologic reaction catalyzed by this isoform. Excellent CA XIII activating properties were shown by D-amino acids (His, Phe, DOPA, and Trp), serotonin, and 4-(2-aminoethyl)-morpholine, whereas the corresponding L-amino acids, dopamine, histamine, and 1-(2-aminoethyl)-piperazine, were weaker activators.

DOI： 10.1016/j.bmcl.2006.05.023

Carbonic anhydrase activators: Activation of isozyme XIII with amino acids and amines

Bioorganic & Medicinal Chemistry Letters 2006.0

Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines

Bioorganic & Medicinal Chemistry Letters 2009.0

Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines

Bioorganic & Medicinal Chemistry Letters 2008.0

Carbonic anhydrase activators: Activation of the human isoforms VII (cytosolic) and XIV (transmembrane) with amino acids and amines

Bioorganic & Medicinal Chemistry Letters 2007.0

Carbonic anhydrase activators: Activation of the human tumor-associated isozymes IX and XII with amino acids and amines

Bioorganic & Medicinal Chemistry 2008.0

Carbonic anhydrase activators: An activation study of the human mitochondrial isoforms VA and VB with amino acids and amines