Design and synthesis of selective α1B adrenoceptor antagonists

Design and synthesis of selective α1B adrenoceptor antagonists 4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]- piperazinyl]-6,7-dimethoxyquinazoline (L-765,314):  A Potent and Selective α_1b Adrenergic Receptor Antagonist Arylsulfonamide derivatives of (aryloxy)ethyl pyrrolidines and piperidines as α 1 -adrenergic receptor antagonist with uro-selective activity α-Adrenoceptor antagonistic and hypotensive properties of novel arylpiperazine derivatives of pyrrolidin-2-one Design and Synthesis of Novel α_1a Adrenoceptor-Selective Dihydropyridine Antagonists for the Treatment of Benign Prostatic Hyperplasia Synthesis and Structure−Affinity Relationship Investigations of 5-Heteroaryl-Substituted Analogues of the Antipsychotic Sertindole. A New Class of Highly Selective α₁Adrenoceptor Antagonists α₁-Adrenoceptor Antagonists. 6. Structural Optimization of Pyridazinone−Arylpiperazines. Study of the Influence on Affinity and Selectivity of Cyclic Substituents at the Pyridazinone Ring and Alkoxy Groups at the Arylpiperazine Moiety New Pyrimido[5,4-b]indoles as Ligands for α₁-Adrenoceptor Subtypes Synthesis and biological affinity of new imidazo- and indol-arylpiperazine derivatives: Further validation of a pharmacophore model for α1-adrenoceptor antagonists 2-[[[2-(2,6-Dimethoxyphenoxy)ethyl]amino]methyl]-1,4-benzoxathian: a new antagonist with high potency and selectivity towards .alpha.1-adrenoreceptors